Diagnostic value of duodenal antitissue transglutaminase antibodies in gluten-sensitive enteropathy
نویسندگان
چکیده
منابع مشابه
IgA anti-tissue transglutaminase as a diagnostic marker of gluten sensitive enteropathy.
AIMS To compare and contrast the sensitivity, specificity, and positive predictive values of IgA antibodies to guinea pig tissue transglutaminase (ELISA), endomysium, and reticulin (immunofluorescence), and gliadin (ELISA), and IgG antibodies to gliadin and tissue transglutaminase. METHODS Sera from 27 newly diagnosed patients with coeliac disease, 65 biopsied gastrointestinal disease control...
متن کاملGluten-sensitive enteropathy: Synthesis
The intestinal mucosa of patients with gluten-sensitive enteropathy responds to gluten challenge in vivo with a striking increase in IgA and IgM synthesis. Whether this increase in immunoglobulin synthesis is due in some part to the production of antigliadin antibodies is examined. Using an affinity chromatography technique it has been demonstrated that in six of seven patients with gluten-sens...
متن کاملRecombinant human tissue transglutaminase ELISA for the diagnosis of gluten-sensitive enteropathy.
BACKGROUND Tissue transglutaminase (TGc) has recently been identified as the major, if not the sole, autoantigen of gluten-sensitive enteropathy (GSE). We developed and validated an ELISA based on the human recombinant antigen and compared it to existing serological tests for GSE [guinea pig TGc ELISA and endomysium antibody (EMA) test]. METHODS Human TGc was expressed in the human embryonic ...
متن کاملIgA class reticulin antibodies of human subtype in gluten sensitive enteropathy.
Epithelial dysplasia is frequently seen adjacent to cholangiocarcinoma in the intra' and extrahepatic bile ducts' and carcinoma of the gall bladder which has a similar epithelial lining.' Extensive severe epithelial dysplasia involving the gall bladder, cystic duct, and common bile duct, associated with adenocarcinoma of the common hepatic duct, was recently reported in a patient with primary s...
متن کاملThe existence of inflammatory bowel lesions in gluten-sensitive enteropathy.
Three patients with coincident coeliac disease and inflammatory bowel disease are described. In 2 patients with known coeliac disease the recurrence of diarrhoea was not due to dietary deviation but to an additional large bowel pathology.
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ژورنال
عنوان ژورنال: Alimentary Pharmacology & Therapeutics
سال: 2008
ISSN: 0269-2813,1365-2036
DOI: 10.1111/j.1365-2036.2008.03652.x